منابع مشابه
Spin-labeled hemoglobin.
In the present paper we describe the results of a preliminary study of the paramagnetic resonance spectrum of spin-labeled horse hemoglobin in solution. Our results provide strong evidence that on oxygenation the A chains undergo a significant structural change near the "reactive" sulfhydryl group (f693), a change not yet resolved by X-ray diffraction.' We also find features in the paramagnetic...
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In the next few minutes I shall present a very brief discussion of what the spin-label technique is, and how it may be used to study biological membranes, x, 2 A "spin label" is a synthetic organic paramagnetic free radical. Most spin
متن کاملSpin-labeled biomolecules.
are remarkably stable and inert,1 and show sharp, well-resolved, and simple paramagnetic resonance spectra2 that are sensitive to molecular motion,3 and, to a lesser extent, sensitive to polarity of the molecular environment.4 As shown below, such nitroxide radicals containing an isocyanate group can be bound to proteins and synthetic polypeptides in a manner similar to that used previously to ...
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greater in older age groups and is increasingly so in the most recent year period population. Not only is the ineaii age at diagnosis increasing, but the rate of incidence is rising much more rapidly in the older age groups as time goes on. In cancer of the skin where increased stimuli from external environmental agents of theoretically possible carcinogenic potentialities are encountered throu...
متن کاملArterial Spin Labeled Perfusion MRI
Perfusion refers to the delivery of oxygen and nutrients to tissues by means of blood flow and is one of the most fundamental physiological parameters. Disorders of perfusion also account for most of the leading causes of medical disability and mortality. While measurements of perfusion are of direct diagnostic value in vascular disorders, perfusion measurements also serve as biomarkers for a b...
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ژورنال
عنوان ژورنال: Il Farmaco
سال: 1999
ISSN: 0014-827X
DOI: 10.1016/s0014-827x(99)00083-x